Hydrocarbon-Stapled GP41 Immunogens
Loren Walensky of the Dana-Farber Cancer Institute in the U.S. will apply a new chemical technology to engineer structurally stable HIV-1 antigens for vaccine development. Walensky will test whether preserving the critical biologically active shape of HIV-1 polypeptides will yield neutralizing antibodies upon vaccination with his laboratory's synthetic immunogens.