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Gene Silencing For Antimalarial Target Identification

Choukri Ben Mamoun of Yale University in the U.S. will work to provide proof-of-principle that a new technology for down-regulating the expression of genes in the malaria-causing parasite P. falciparum can be used to identify specific drug targets. Antimalarial compounds in the Malaria Box will be screened against altered parasite strains to determine modes of action and to identify specific cellular targets to be pursued in future drug development.

More information about New Approaches for the Interrogation of Anti-Malarial Compounds (Round 9)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.