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Gene Locking: Sequence-Specific Targeting of Mycobacterium Tuberculosis

Samantha Sampson of Imperial College London proposes introducing short strands of modified DNA into tuberculosis cells for direct and highly specific targeting of DNA sequences. If successful, it will effectively "lock" DNA, obstruct replication and transcription, and prevent bacterial growth and survival.

More information about Create Drugs and Delivery Systems to Limit Drug Resistance (Round 1)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.