Elimination of ADE-Induced Dengue Virus Infection by a Novel Reagent DCAF

Shan Feng of Tsinghua University in China will develop a novel reagent called DCAF to eliminate antibody-dependence-enhanced (ADE) Dengue virus infection. DCAF stands for Dual-functional Conjugate of Antigenic peptide and Fc-III tag, which is designed for the blocking of cross-reactive antibodies that can enhance secondary infection of Dengue virus. In the current phase, they will synthesize a group of DCAF molecules to test their binding affinities with the antibodies of Dengue virus 2 and to evaluate whether these molecules can be used to block the ADE process.