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Discovery of Tat-mimicking Compounds to Fight HIV Latency

Marco Sgarbanti at the Istituto Superiore di Sanità in Italy proposes to develop a new class of small molecules designed to mimic Tat gene products found in HIV that stimulate and accelerate the transcription of HIV RNA. These Tat-mimicking compounds could activate the latent virus, creating an opportunity to expose it to effective antiretroviral therapies.

More information about Design New Approaches to Cure HIV Infection (Round 6)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.