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Development of a Novel Humanized Microbiome Mouse Model for Cryptosporidiosis

Jan Mead of Emory University in the U.S. will develop a mouse model of cryptosporidiosis using human fecal transplants to mimic changes in the bacterial populations (microbiome) in the gut that occur in the human disease, which causes substantial morbidity and mortality in young children from developing countries. Drugs used to eradicate the intestinal parasite Cryptosporidium are thought to be affected by the levels and types of bacteria that populate the human gut, which is of particular importance in malnourished children who most often become infected. They will colonize germ-free mice with human fecal material and infect them with Cryptosporidium. The effect of the infection and of selected drugs on the microbiome will then be evaluated by DNA sequencing.

More information about Accelerate Development of New Therapies for Childhood Cryptosporidium Infection (Round 17)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.