Catherine Tuleu of University College London in the United Kingdom will develop a rectal formulation of the antibiotic amoxicillin tailored specifically for children with pneumonia particularly in developing countries that can be stored long-term in hot climates. Suppositories are easy to administer, and avoid the bad taste of the antibiotic or the need to swallow a tablet, which is often difficult for children. They have already characterized several suppository bases and will test different excipients to provide stability at high temperatures. These formulations will be evaluated for quality and stability, and speed of drug release will be compared with current tablet and capsule forms.
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