Skip to main content

Grand Challenges

Bill & Melinda Gates Foundation

Main menu

  • About
  • Challenges
  • Awarded Grants
  • News
  • Grant Opportunities
  • Search

You are here

  1. Home
  2. Awarded Grants

Print link

Print

Autophagy as a Cell-Autonomous Mechanism of HIV Control

Grand Challenges ExplorationsHIV Infection1 Oct 2008

Vojo Deretic of the University of New Mexico in the U.S. proposed that autophagy, a process by which cells destroy cellular components and intracellular pathogens, can be induced through drug therapy to not only destroy the HIV virus in infected cells, but also to block its transmission from dendritic cells to T cells. This project's Phase I research demonstrated that autophagy can destroy HIV, block dendritic to T cell transfer of HIV, and promote antigen presentation by dendritic cells. In Phase II, Deretic's team will screen for compounds that can induce autophagy to block HIV from infecting cells, limit HIV spread, and enhance dendritic cell immune functions.

More information about Create New Ways to Prevent or Cure HIV Infection (Round 1)

Share This Awarded Grant

  • Twitter logo Twitter
  • Facebook logo Facebook
  • LinkedIn logo LinkedIn
  • Google+ logo Google+
  • Mailto logo Mailto

Principal Investigator

Vojo Deretic

Organization

University of New Mexico

Location

Albuquerque, New Mexico
United States

Contact us

Contact us

  • General Inquiries
  • Media Inquiries

Footer - Receive Updates

Receive updates

  • Sign up for email updates

Footer

  • Privacy Policy and Terms of Use
© 2003-2019. Grand Challenges. All Rights Reserved.

PLEASE REVIEW OUR UPDATED PRIVACY & COOKIES NOTICE

This site uses cookies and similar technologies to store information on your computer or device. By continuing to use this site, you agree to the placement of these cookies and similar technologies. Read our updated Privacy & Cookies Notice to learn more.