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Antihistamine Use for Enhanced Macrofilaricidal Activity

Edward Mitre and colleagues at the Henry M. Jackson Foundation for the Advancement of Military Medicine in the U.S. will develop a short course therapy for clearing adult filarial worms, which cause substantial morbidity and mortality, to enhance eradication efforts. Current antifilarial medications target only larval forms of the worms, requiring repeated administration until the natural death of the adults. Filarial infections are known to induce immune cells to release histamine, which can regulate the immune response. Using mouse models of filarial infections, they will evaluate whether a short course of standard antifilarial treatment combined with an antihistamine can clear adult worms and thereby more quickly cure the disease.

More information about New Approaches for Detection, Treatment, and Control of Selected Neglected Tropical Diseases (Round 11)

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The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.