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Antagonist of RNA-Protein Interactions as Activators of A3G

A3G, protein found in human cells that inactivates several viruses including HIV, is "switched off" in proliferating T cells. Harold Smith of the University of Rochester will screen for small molecule compounds that bind to A3G in cells and turn its anti-viral activity back on.

More information about Create Drugs and Delivery Systems to Limit Drug Resistance (Round 1)

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View the Grand Challenges partnership network

The Bill & Melinda Gates Foundation is part of the Grand Challenges partnership network. Visit www.grandchallenges.org to view the map of awarded grants across this network and grant opportunities from partners.