The Gates Foundation is part of the Grand Challenges partnership network. Visit <a href="https://www.grandchallenges.org" target="_blank">www.grandchallenges.org</a> to view the map of awarded grants across this network and grant opportunities from partners.

Grand Challenges supports exceptional scientists with the expertise to do breakthrough R&amp;D as well as the experience, networks, and skills to excel as scientific leaders. These champions co-create projects with global partners, mobilize key institutions in their countries, and improve public health in their communities and around the world.

Grand Challenges funds innovations to tackle the biggest problems in global health and development. Since 2004, through the Grand Challenges program, we have supported more than 2500 innovation projects in more than 90 countries.

For more than 20 years, Grand Challenges has built trusted relationships with global health funders and researchers. We tap into this powerful network to create unique scientific collaborations with a transformative impact on people's lives.

Innovation happens all along the journey from idea, to experiment, to product or policy, and finally to delivery at scale in communities. We fund innovation projects while supporting an environment of champions, systems, and partnerships to maximize the impact these projects make in people's lives.

The 4 Pillars of the Grand Challenges Ecosystem

Doing groundbreaking science requires the right mix of institutions, policies, and tools. Grand Challenges works with partners in low- and middle-income countries to build or strengthen the capacities they need to succeed in R&amp;D.

African Scientific Leaders Outline Focused Actions to Strengthen Health R&D

While national and regional policies have sought to address long-standing barriers within Africa’s R&D ecosystem, many challenges persist, particularly at the operational level. The Calestous Juma Science Leadership Fellows now outline actionable pathways to unlock Africa’s health research potential, actively calling on researchers, policymakers, implementers, funders, and governments to collaboratively contribute to reshaping and enabling the continent’s R&D landscape.In a <a href="https://www.nature.com/articles/s44360-025-00015-8" target="_blank">commentary</a> recently published in Nature Health, the Fellows argue that “the challenges we face as Africans in the current rapidly changing international funding environment underscore the importance of engaging in relevant actions to collectively shape a bright future for African R&D.” The full paper can be found on <a href="https://gatesopenresearch.org/documents/9-59" target="_blank">Gates Open Research</a>.

On November 7, 2011, more than 100 researchers from around the world were awarded Grand Challenges Explorations grants. Each will receive $100,000 to conduct innovative, early-stage research projects focusing on global health and development topics such as nutrition, infectious disease, sanitation, and immunization strategies. Some of the winners are featured here.

On November 7, 2011, more than 100 researchers from around the world were awarded Grand Challenges Explorations grants. Each will receive $100,000 to conduct innovative, early-stage research projects focusing on global health and development topics such as nutrition, infectious disease, sanitation, and immunization strategies. Some of the winners are featured here.

Grand Challenges Explorations Round 7 Highlights

Explore Nutrition for Healthy Growth of Infants and Children (Round 7)

Ricardo Radulovich of the University of Costa Rica/FUNDEVI is scaling up sustainable seaweed farming ventures in Costa Rica to formulate the crops into a nutritious, low-cost stand-alone food or supplement.

Farmed-Seaweed Meal as Food or Supplement

Grand Challenges Explorations: Fostering New Ideas in Global Health and Development

Grand Challenges Explorations

Photo Galleries

Photo Gallery

Kevin Nicholas of Deakin University in Australia is studying the milk composition of lactating tammar wallabies to identify proteins - and then their human equivalents - that promote gut functioning and stomach development in infants. These human proteins could be developed into a supplement for preterm and low birth weight babies.

Improved Gut Development and Function in Preterm/LBW Babies

Nutrition for Infants and Children: Improving Gut Development and Function in Newborns

Kiersten Israel-Ballard of the Program for Appropriate Technology in Health (PATH) in the U.S., working with the University of Washington and Human Milk Banking (HMB) Association of South Africa, is developing a low-cost, cell-phone sensing system to monitor flash-heating pasteurization of breast milk for donation to vulnerable infants.

Use of Low Technology for Donor Breast Milk Banking

Nutrition for Infants and Children: Using Low-Cost Technology for Donor Breast Milk Banking

Jacob Godfrey Agea of Makerere University in Uganda will breed Nsenene grasshoppers, which are a rich source of protein, and mill them for use as flour or an additive in foods such as cereals and grains for infants and children.
Photo courtesy of Fred Mugira

Breeding and Rearing Nsenene Grasshoppers as Protein Source

Nutrition for Infants and Children: Breeding Grasshoppers as a Protein Source

Alistair McEwan of The University of Sydney in Australia is developing a low-cost, easy-to-use electronic device that uses LEDs, solar cells and inexpensive components to measure subcutaneous fat levels and detect malnutrition in newborns.

Malnutrition and Body Composition Assessment for Under $1

Nutrition for Infants and Children: Assessing Malnutrition and Body Composition for Less than $1

Apply Synthetic Biology to Global Health Challenges (Round 7)

Mark van Raaij of the Spanish National Research Council at the National Center for Biotechnology in Spain is building a library of engineered viruses (bacteriophages) that can recognize, infect, and kill a range of bacterial pathogens such as Salmonella and E. coli.

A Method to Generate Bacteriophages Targeting Enterobacteria

Synthetic Biology: Engineering Viruses to Target Bacterial Pathogens

Virginia Cornish and Nili Ostrov at Columbia University in the U.S. are engineering baker’s yeast to produce a natural red pigment upon exposure to the cholera pathogen in drinking water. This safe and simple sensor could be inexpensively manufactured for household monitoring of cholera in communities at risk for infection.

A Household Yeast Biosensor for Cholera

Synthetic Biology: A Household Biosensor for Cholera

Matt Cottingham of The Jenner Institute at the University of Oxford in the United Kingdom is engineering a vaccine vector that uses HIV antigens and the immune evasion genes of cytomegalovirus (CMV) for use in an HIV vaccine that could elicit a strong immune response without safety issues that typically accompany the use of CMV in vaccines.

Adenoviral HIV Vaccine Vector with CMV-Like Immunogenicity

Synthetic Biology: Developing an HIV Vaccine Technology

Design New Approaches to Cure HIV Infection (Round 7)

Mario Ostrowski of the University of Toronto in Canada is testing the ability of endogenous retrovirus antigens to mark HIV infected cells, providing a basis for the development of a new HIV vaccine.

A Human Endogenous Retrovirus Vaccine to Eliminate Latent HIV

Curing HIV: Testing Endogenous Retroviruses as a Vaccine Component to Eliminate Latent HIV

Phillip M. Gerk of Virginia Commonwealth University in the U.S. is testing the ability of fatty acid transporters to deliver antiretroviral drugs to the central nervous system and to lymphatic tissues in the gut, which provide sanctuary for latent HIV.

Eradicating HIV Infection: Eliminate HIV Viral Sanctuaries

Curing HIV: Delivering Antiretroviral Drugs to Latent HIV Sanctuaries

Seth Pincus of Children's Hospital New Orleans in the U.S. is studying how the depletion of CD4+ memory cells harboring latent HIV might affect the latent HIV reservoir and the immune system in general.

Depletion of CD45RO+ Cells to Eliminate the Latent Reservoir

Curing HIV: Depleting Memory Cells To Eliminate Latent HIV

Create the Next Generation of Sanitation Technologies (Round 7)

Jason Aramburu of re:char in the U.S. will use low-cost pyrolysis reactors to convert human waste into biochar, which can be used as a replacement for wood charcoal or chemical fertilizers.

Conversion of Human Excreta to Energy and Biochar

Sanitation Solutions: Converting Human Waste to Biochar

Taber Hand of Wetlands Work! in Cambodia is testing a unique waste water treatment system for use under toilets of houseboats in floating villages in Southeast Asia. Floating "pods" similar to children’s wading pools are filled with plants whose roots trap the organic matter, breaking down the waste and filtering the water.

Floating Community Wastewater Treatment in Asia

Sanitation Solutions: Treating Waste in Floating Villages in Asia

Zhiyong Ren of the University of Colorado Denver in the U.S. is developing a low-cost and easy-to-operate bioelectric system that uses microbes to break down waste and convert it to usable electricity.

Direct Electricity from Fecal Sludge in Bioelectric Systems

Sanitation Solutions: Direct Electricity from Fecal Sludge in Bioelectric Systems

Yuanbing Mao of the University of Texas-Pan American in the U.S. is developing spray paints that use nanomaterials to trap contaminants and convert UV light to destroy the pathogens. These spray paints could be used as decontaminating coatings for latrines.

Spray Paints for Self-Decontaminating Latrine Coatings

Sanitation Solutions: Spray Paints for Self-Decontaminating Latrine Coatings

Create Low-Cost Cell Phone-Based Solutions for Improved Uptake and Coverage of Childhood Vaccination (Round 7)

Richard Fletcher of Massachusetts General Hospital Center for Global Health in the U.S., in collaboration with Massachusetts Institute of Technology, is developing a cell phone system that can capture images of hand vein patterns for patient identification, GPS-tag it to track location information, and scan labels on vaccine doses to assess the quality and its expiration date.

Low Cost Method for Automating Vaccination Records, Patient Identification, and Improving Vaccine Safety

Cell Phone Health Applications: Using Cell Phones to Aid Vaccination Campaigns

Elizabeth Belding and Amr El Abbadi of the University of California at Santa Barbara in the U.S. are testing a low-cost cellular architecture with an integrated information system that can determine a child’s immunization status, disseminate vaccine-related information, and track at-risk populations.

ImmuNet: Targeted Immunization for Infants and Children

Cell Phone Health Applications: Tracking Immunizations for Infants and Children

The Poliovirus Endgame: Create Innovative Ways to Accelerate, Sustain, and Monitor Eradication (Round 7)

Satoshi Kashiwagi of Massachusetts General Hospital in the U.S. is researching whether pre-treating the skin at the site of a vaccination with an infrared laser can stimulate a stronger immune response to the polio vaccination. This laser-based technology could reduce the number of vaccinations required to protect children from polio.

Dermal Laser for Dose Sparing of Pediatric Polio Vaccine

Eradicating Poliovirus: Using a Dermal Laser to Stimulate a Stronger Vaccine Response

Mark Prausnitz of Georgia Institute of Technology and Steve Oberste of the Centers for Disease Control and Prevention in the U.S. are testing the use of microneedle patches to deliver the inactivated polio vaccine (IPV) instead of using intramuscular vaccine shots. This new method could lower the required dose, simplify vaccination procedures, and eliminate dangers associated with hypodermic needles.