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Grand Challenges

Bill & Melinda Gates Foundation

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Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

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Novel Approaches for Improving Timeliness of Routine Immunization Birthdose and Healthcare Worker Skill in Low-Resource Settings (Round 20)

Grand Challenges Explorations
6 Sep 2017

Health Systems Strengthening: Ensuring Effective Health Supply Chains (Round 19)

Grand Challenges Explorations
7 Mar 2017

New Approaches for Improving Timeliness of Routine Immunizations in Low-Resource Settings (Round 19)

Grand Challenges Explorations
7 Mar 2017

Wearables and Technology for Maternal, Neonatal and Child Health Behavior Change (Round 19)

Grand Challenges Explorations
7 Mar 2017
Round 19 - Daignostics

Innovations for Integrated Diagnostics Systems (Round 19)

Grand Challenges Explorations
7 Mar 2017

New Interventions for Global Health: Vaccine Manufacturing

Grand Challenges
8 Sep 2015

Explore New Solutions in Global Health Priority Areas (Round 16)

Grand Challenges Explorations
8 Sep 2015

Novel Approaches to Characterizing and Tracking the Global Burden of Antimicrobial Resistance (Round 16)

Grand Challenges Explorations
8 Sep 2015

Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering (Round 16)

Grand Challenges Explorations
8 Sep 2015

Explore New Ways to Measure Delivery and Use of Digital Financial Services Data (Round 16)

Grand Challenges Explorations
8 Sep 2015

Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering (Round 15)

Grand Challenges Explorations
26 Feb 2015

Explore New Ways to Measure Delivery and Use of Digital Financial Services Data (Round 15)

Grand Challenges Explorations
26 Feb 2015

Surveillance Tools, Diagnostics and an Artificial Diet to Support New Approaches to Vector Control (Round 15)

Grand Challenges Explorations
26 Feb 2015

New Approaches for Addressing Outdoor/Residual Malaria Transmission (Round 15)

Grand Challenges Explorations
26 Feb 2015

New Ways to Reduce Childhood Pneumonia Deaths Through Delivery of Timely Effective Treatment (Round 15)

Grand Challenges Explorations
26 Feb 2015

Enable Merchant Acceptance of Mobile Money Payments (Round 15)

Grand Challenges Explorations
26 Feb 2015

Saving Lives at Birth (Round 5)

Grand Challenges for Development
9 Feb 2015
Biological Vector Control

Develop a Biological Strategy to Deplete or Incapacitate a Disease-transmitting Insect Population

Grand Challenges in Global Health
1 Dec 2003
Crop Biofortification

Create a Full Range of Optimal, Bioavailable Nutrients in a Single Staple Plant Species

Grand Challenges in Global Health
1 Dec 2003
Create Effective Single Dose Vaccines That Can Be Used Soon After Birth

Create Effective Single Dose Vaccines That Can Be Used Soon After Birth

Grand Challenges in Global Health
1 Dec 2003
Protective Immunity

Learn Which Immunological Responses Provide Protective Immunity

Grand Challenges in Global Health
1 Dec 2003
Drug Resistance

Discover Drugs and Delivery Systems that Minimize the Likelihood of Drug Resistant Micro-organisms

Grand Challenges in Global Health
1 Dec 2003

Devise Reliable Tests in Model Systems to Evaluate Live Attenuated Vaccines

Grand Challenges in Global Health
1 Dec 2003
Curing Chronic Infection

Create Immunological Methods that can Cure Chronic Infections

Grand Challenges in Global Health
1 Dec 2003
Develop Needle-Free Delivery Systems

Develop Needle-Free Delivery Systems

Grand Challenges in Global Health
1 Dec 2003

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