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Bill & Melinda Gates Foundation

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Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

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2018 Grand Challenges Annual Meeting Call-to-Action

Grand Challenges
19 Oct 2018

Ending the Pandemic Threat: A Grand Challenge for Universal Influenza Vaccine Development

Grand Challenges
27 Apr 2018

Campylobacter spp. Transmission Dynamics in Low- and Middle-Income Countries

Grand Challenges
5 Mar 2018
Biological Vector Control

Develop a Biological Strategy to Deplete or Incapacitate a Disease-transmitting Insect Population

Grand Challenges in Global Health
1 Dec 2003
Crop Biofortification

Create a Full Range of Optimal, Bioavailable Nutrients in a Single Staple Plant Species

Grand Challenges in Global Health
1 Dec 2003
Create Effective Single Dose Vaccines That Can Be Used Soon After Birth

Create Effective Single Dose Vaccines That Can Be Used Soon After Birth

Grand Challenges in Global Health
1 Dec 2003
Protective Immunity

Learn Which Immunological Responses Provide Protective Immunity

Grand Challenges in Global Health
1 Dec 2003
Drug Resistance

Discover Drugs and Delivery Systems that Minimize the Likelihood of Drug Resistant Micro-organisms

Grand Challenges in Global Health
1 Dec 2003

Devise Reliable Tests in Model Systems to Evaluate Live Attenuated Vaccines

Grand Challenges in Global Health
1 Dec 2003
Curing Chronic Infection

Create Immunological Methods that can Cure Chronic Infections

Grand Challenges in Global Health
1 Dec 2003
Develop Needle-Free Delivery Systems

Develop Needle-Free Delivery Systems

Grand Challenges in Global Health
1 Dec 2003
Antigen Design

Solve How to Design Antigens for Effective, Protective Immunity

Grand Challenges in Global Health
1 Dec 2003
Create Therapies that Can Cure Latent Infection

Create Therapies that Can Cure Latent Infection

Grand Challenges in Global Health
1 Dec 2003
Prepare Vaccines that Do Not Require Refrigeration

Prepare Vaccines that Do Not Require Refrigeration

Grand Challenges in Global Health
1 Dec 2003
Chemical Vector Control

Develop a Chemical Strategy to Deplete or Incapacitate a Disease-transmitting Insect Population

Grand Challenges in Global Health
1 Dec 2003
Develop Technologies that Permit Quantitative Assessment of Population Health Status

Develop Technologies that Permit Quantitative Assessment of Population Health Status

Grand Challenges in Global Health
1 Dec 2003
Point-of-Care Diagnostics

Develop Technologies that Allow Assessment of Multiple Conditions and Pathogens at Point-of-Care

Grand Challenges in Global Health
1 Dec 2003
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