Challenges

Grand Challenges is a family of initiatives fostering innovation to solve key global health and development problems. Each initiative is an experiment in the use of challenges to focus innovation on making an impact. Individual challenges address some of the same problems, but from differing perspectives.

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Create New Ways of Protecting Against Infectious Diseases (Round 1)

Grand Challenges Explorations
31 Mar 2008

Create Drugs and Delivery Systems to Limit Drug Resistance (Round 1)

Grand Challenges Explorations
31 Mar 2008

Explore the Basis of Latency in Tuberculosis (Round 1)

Grand Challenges Explorations
31 Mar 2008

Create New Ways to Prevent or Cure HIV Infection (Round 1)

Grand Challenges Explorations
31 Mar 2008

Create New Ways to Prevent or Cure HIV Infection (Round 2)

Grand Challenges Explorations
3 Sep 2008

Create New Vaccines for Diarrhea, HIV, Malaria, Pneumonia, and Tuberculosis (Round 2)

Grand Challenges Explorations
3 Sep 2008

Create New Ways of Protecting Against Infectious Diseases (Round 2)

Grand Challenges Explorations
3 Sep 2008

Create New Tools to Accelerate the Eradication of Malaria (Round 2)

Grand Challenges Explorations
3 Sep 2008

Create Drugs and Delivery Systems to Limit Drug Resistance (Round 2)

Grand Challenges Explorations
3 Sep 2008

Explore the Basis of Latency in Tuberculosis (Round 2)

Grand Challenges Explorations
3 Sep 2008

Create New Tools to Accelerate the Eradication of Malaria (Round 3)

Grand Challenges Explorations
2 Apr 2009

Create New Vaccines for Diarrhea, HIV, Malaria, Pneumonia, and Tuberculosis (Round 3)

Grand Challenges Explorations
2 Apr 2009

Create New Ways to Induce Mucosal Immunity (Round 3)

Grand Challenges Explorations
2 Apr 2009

Create Low-Cost Diagnostics for Priority Global Health Conditions (Round 3)

Grand Challenges Explorations
2 Apr 2009

Create New Ways to Protect Against Infectious Disease (Round 4)

Grand Challenges Explorations
2 Sep 2009

Create Low-Cost Diagnostics for Priority Global Health Conditions (Round 4)

Grand Challenges Explorations
2 Sep 2009

Create New Ways to Induce and Measure Mucosal Immunity (Round 4)

Grand Challenges Explorations
2 Sep 2009

Create New Technologies for Contraception (Round 4)

Grand Challenges Explorations
2 Sep 2009

Create New Technologies for Contraception (Round 5)

Grand Challenges Explorations
25 Mar 2010

Create New Technologies to Improve the Health of Mothers and Newborns (Round 5)

Grand Challenges Explorations
25 Mar 2010

Create New Ways to Protect Against Infectious Disease (Round 5)

Grand Challenges Explorations
25 Mar 2010

Create Low-Cost Cell Phone-Based Applications for Priority Global Health Conditions (Round 5)

Grand Challenges Explorations
25 Mar 2010

Create the Next Generation of Sanitation Technologies (Round 6)

Grand Challenges Explorations
19 Aug 2010

Design New Approaches to Cure HIV Infection (Round 6)

Grand Challenges Explorations
19 Aug 2010

The Poliovirus Endgame: Create ways to Accelerate, Sustain and Monitor Eradication (Round 6)

Grand Challenges Explorations
19 Aug 2010

Create Low-Cost Cell Phone-Based Applications for Priority Global Health Conditions (Round 6)

Grand Challenges Explorations
19 Aug 2010

Create New Technologies to Improve the Health of Mothers and Newborns (Round 6)

Grand Challenges Explorations
19 Aug 2010

Apply Synthetic Biology to Global Health Challenges (Round 7)

Grand Challenges Explorations
15 Mar 2011

Create the Next Generation of Sanitation Technologies (Round 7)

Grand Challenges Explorations
15 Mar 2011

Design New Approaches to Cure HIV Infection (Round 7)

Grand Challenges Explorations
15 Mar 2011

Explore Nutrition for Healthy Growth of Infants and Children (Round 7)

Grand Challenges Explorations
15 Mar 2011

Create Low-Cost Cell Phone-Based Solutions for Improved Uptake and Coverage of Childhood Vaccination (Round 7)

Grand Challenges Explorations
15 Mar 2011

The Poliovirus Endgame: Create Innovative Ways to Accelerate, Sustain, and Monitor Eradication (Round 7)

Grand Challenges Explorations
15 Mar 2011

China Tsinghua University - Grand Challenges Explorations

Grand Challenges Explorations
1 Apr 2011

Explore New Solutions for Global Health Priority Areas (Round 8)

Grand Challenges Explorations
23 Aug 2011

Apply Synthetic Biology to Global Health Challenges (Round 8)

Grand Challenges Explorations
23 Aug 2011

Explore Nutrition for Healthy Growth of Infants and Children (Round 8)

Grand Challenges Explorations
23 Aug 2011

Design New Approaches to Optimize Immunization Systems (Round 8)

Grand Challenges Explorations
23 Aug 2011

Protect Crop Plants from Biotic Stresses From Field to Market (Round 8)

Grand Challenges Explorations
23 Aug 2011

Design New Approaches to Optimize Immunization Systems (Round 9)

Grand Challenges Explorations
29 Feb 2012

Aid is Working. Tell the World. (Round 9)

Grand Challenges Explorations
29 Feb 2012

Explore New Solutions for Global Health Priority Areas (Round 9)

Grand Challenges Explorations
29 Feb 2012

Protect Crop Plants from Biotic Stresses From Field to Market (Round 9)

Grand Challenges Explorations
29 Feb 2012

New Approaches for the Interrogation of Anti-malarial Compounds (Round 9)

Grand Challenges Explorations
29 Feb 2012

New Approaches in Model Systems, Diagnostics, and Drugs for Specific Neglected Tropical Diseases (Round 10)

Grand Challenges Explorations
5 Sep 2012

Labor Saving Innovations for Women Smallholder Farmers (Round 10)

Grand Challenges Explorations
5 Sep 2012

Aid is Working. Tell the World. (Round 10)

Grand Challenges Explorations
5 Sep 2012

New Approaches for the Interrogation of Anti-malarial Compounds (Round 10)

Grand Challenges Explorations
5 Sep 2012

Labor Saving Strategies and Innovations for Women Smallholder Farmers (Round 11)

Grand Challenges Explorations
4 Mar 2013

New Approaches for Detection, Treatment, and Control of Selected Neglected Tropical Diseases (Round 11)

Grand Challenges Explorations
4 Mar 2013

Develop the Next Generation of Condom (Round 11)

Grand Challenges Explorations
4 Mar 2013

The One Health Concept: Bringing Together Human and Animal Health for New Solutions (Round 11)

Grand Challenges Explorations
4 Mar 2013

Increasing Interoperability of Social Good Data (Round 11)

Grand Challenges Explorations
4 Mar 2013

Develop the Next Generation of Condom (Round 12)

Grand Challenges Explorations
5 Sep 2013

Innovations in Feedback and Accountability Systems for Agricultural Development (Round 12)

Grand Challenges Explorations
5 Sep 2013
Enteric Dysfunction

Novel Enabling Tools and Models Supporting Development of Interventions for Enteric Dysfunction (Round 12)

Grand Challenges Explorations
5 Sep 2013

The One Health Concept: Bringing Together Human and Animal Health for New Solutions (Round 12)

Grand Challenges Explorations
5 Sep 2013

Inciting Healthy Behaviors: Nudge, Disrupt, Leapfrog, Reach (Round 12)

Grand Challenges Explorations
5 Sep 2013

New Ways of Working Together: Community-Based Interventions (Round 13)

Grand Challenges Explorations
4 Mar 2014

Inciting Healthy Behaviors: Nudge, Disrupt, Leapfrog, Reach (Round 13)

Grand Challenges Explorations
4 Mar 2014

Explore New Ways to Measure Fetal and Infant Brain Development (Round 13)

Grand Challenges Explorations
4 Mar 2014
Enteric Dysfunction

Novel Enabling Tools and Models Supporting Development of Interventions for Enteric Dysfunction (Round 13)

Grand Challenges Explorations
4 Mar 2014

Innovations in Feedback and Accountability Systems for Agricultural Development (Round 13)

Grand Challenges Explorations
4 Mar 2014

Explore New Ways to Measure Brain Development and Gestational Age (Round 14)

Grand Challenges Explorations
8 Sep 2014

New Ways to Reduce Pneumonia Fatalities Through Timely, Effective Treatment of Children (Round 14)

Grand Challenges Explorations
8 Sep 2014

New Ways of Working Together: Integrating Community-Based Intervention (Round 14)

Grand Challenges Explorations
8 Sep 2014

Enable Universal Acceptance of Mobile Money Payments (Round 14)

Grand Challenges Explorations
8 Sep 2014

New Approaches for Addressing Outdoor/Residual Malaria Transmission (Round 14)

Grand Challenges Explorations
8 Sep 2014

Surveillance Tools, Diagnostics and an Artificial Diet to Support New Approaches to Vector Control (Round 14)

Grand Challenges Explorations
8 Sep 2014

Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering (Round 15)

Grand Challenges Explorations
26 Feb 2015

Explore New Ways to Measure Delivery and Use of Digital Financial Services Data (Round 15)

Grand Challenges Explorations
26 Feb 2015

Surveillance Tools, Diagnostics and an Artificial Diet to Support New Approaches to Vector Control (Round 15)

Grand Challenges Explorations
26 Feb 2015

New Approaches for Addressing Outdoor/Residual Malaria Transmission (Round 15)

Grand Challenges Explorations
26 Feb 2015

New Ways to Reduce Childhood Pneumonia Deaths Through Delivery of Timely Effective Treatment (Round 15)

Grand Challenges Explorations
26 Feb 2015

Enable Merchant Acceptance of Mobile Money Payments (Round 15)

Grand Challenges Explorations
26 Feb 2015

Explore New Solutions in Global Health Priority Areas (Round 16)

Grand Challenges Explorations
8 Sep 2015

Novel Approaches to Characterizing and Tracking the Global Burden of Antimicrobial Resistance (Round 16)

Grand Challenges Explorations
8 Sep 2015

Addressing Newborn and Infant Gut Health Through Bacteriophage-Mediated Microbiome Engineering (Round 16)

Grand Challenges Explorations
8 Sep 2015

Explore New Ways to Measure Delivery and Use of Digital Financial Services Data (Round 16)

Grand Challenges Explorations
8 Sep 2015

Assess Family Planning Needs, Preferences and Behaviors to Inform Innovations in Contraceptive Technologies and Services (Round 17)

Grand Challenges Explorations
18 Feb 2016

Develop Novel Platforms to Accelerate Contraceptive Drug Discovery (Round 17)

Grand Challenges Explorations
18 Feb 2016

Design New Analytics Approaches for Malaria Elimination (Round 17)

Grand Challenges Explorations
18 Feb 2016

Accelerate Development of New Therapies for Childhood Cryptosporidium Infection (Round 17)

Grand Challenges Explorations
18 Feb 2016

Novel Approaches to Characterizing and Tracking the Global Burden of Antimicrobial Resistance (Round 17)

Grand Challenges Explorations
18 Feb 2016

Explore New Solutions in Global Health Priority Areas (Round 17)

Grand Challenges Explorations
18 Feb 2016

Accelerate Development of New Therapies for Childhood Cryptosporidium Infection (Round 18)

Grand Challenges Explorations
13 Sep 2016

Develop Novel Platforms to Accelerate Contraceptive Drug Discovery (Round 18)

Grand Challenges Explorations
13 Sep 2016

Design New Solutions to Data Integration for Malaria Elimination (Round 18)

Grand Challenges Explorations
13 Sep 2016

Assess Family Planning Needs, Preferences and Behaviors to Inform Innovations in Contraceptive Technologies (Round 18)

Grand Challenges Explorations
13 Sep 2016

Health Systems Strengthening: Ensuring Effective Health Supply Chains (Round 19)

Grand Challenges Explorations
7 Mar 2017

New Approaches for Improving Timeliness of Routine Immunizations in Low-Resource Settings (Round 19)

Grand Challenges Explorations
7 Mar 2017

Wearables and Technology for Maternal, Neonatal and Child Health Behavior Change (Round 19)

Grand Challenges Explorations
7 Mar 2017
Round 19 - Daignostics

Innovations for Integrated Diagnostics Systems (Round 19)

Grand Challenges Explorations
7 Mar 2017
Adolescent Maternal Health

Healthy Minds for Adolescent Mothers: Achieving Healthy Outcomes for the Family (Round 20)

Grand Challenges Explorations
6 Sep 2017
Round 19 - Daignostics

Innovations for Integrated Diagnostics Systems (Round 20)

Grand Challenges Explorations
6 Sep 2017

Novel Approaches for Improving Timeliness of Routine Immunization Birthdose and Healthcare Worker Skill in Low-Resource Settings (Round 20)

Grand Challenges Explorations
6 Sep 2017

Innovations in Immunization Data Management, Use, and Improved Process Efficiency (Round 21)

Grand Challenges Explorations
5 Mar 2018

Affordable, Accessible, and Appealing: The Next Generation of Nutrition (Round 21)

Grand Challenges Explorations
5 Mar 2018

Tools and Technologies for Broad-Scale Disease Surveillance of Crop Plants in Low-Income Countries (Round 21)

Grand Challenges Explorations
5 Mar 2018

Increasing Demand for Vaccination Services (Round 22)

Grand Challenges Explorations
19 Sep 2018
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